Carcinoma complicating exstrophy of the bladder is rare; we have noted reports of only nineteen cases in the literature, two of which were reported by Scholl1 from the Mayo Clinic. We are adding one case (case 1) which has not been reported previously. So far as we know, cure has not been reported following treatment. In two cases at the Mayo Clinic, however, the patients have remained well for three and six and a half years, respectively, following surgical treatment.
EMBRYOLOGY
It is assumed that the fertilized human embryo, by processes of growth and cell division, soon becomes a solid mass of cells, the morula. The peripheral cells of the morula differentiate and thus form a distinct enveloping layer of cuboidal cells2 (fig. 1 A). Vacuoles which appear within the enclosed mass of cells coalesce to form a single cavity within the enveloping layer. This cavity corresponds to