0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

STUDIES IN ACROMEGALY:  VIII. EXPERIMENTAL CANINE ACROMEGALY PRODUCED BY INJECTION OF ANTERIOR LOBE PITUITARY EXTRACT

TRACY J. PUTNAM; EDWARD B. BENEDICT; HAROLD M. TEEL
Arch Surg. 1929;18(4):1708-1736. doi:10.1001/archsurg.1929.01140130808054.
Text Size: A A A
Published online

The possibility that the peculiar and distinctive disorders, acromegaly and acromegalic gigantism, were due to overactivity of the anterior lobe of the pituitary body has been suspected for many years. Although other data were not lacking to confirm the suggestion, it may be said that the possibility was first transformed into a probability by the production of gigantism in rats by injections of an emulsion of the anterior lobes of beef hypophyses by Evans and Long.1 Their prodigious animals could not actually be considered acromegalic, however. They underwent a general proportionate enlargement, but aside from a peculiar change in the ovaries they showed no qualitative structural alteration. The absence of the specific enlargement of the "acral parts," which gives the disease its name, might be attributed to the fact that in the rat the bony epiphyses never unite. It obviously became desirable to extend the experiment to larger animals

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();