Until the surgeon began to think of bone as a living fabric with qualities other than its hardness and potentialities beyond its mechanics, progress in the rational treatment for diseases and injuries of the skeleton could not proceed. A corresponding total physiologic conception of the peripheral vascular tree has been slow in developing. The peripheral vessels have too long been thought of as more or less elastic tubes of differing calibers, responding only to the mechanical forces developed from the pulse wave and the succeeding elastic recoil. They are not thought of under all circumstances as living structures responding in their own right to nerve impulse as well.
In the light of the rapidly increasing knowledge of the vegetative nervous system, certain aspects of vascular disease are now looked at with a more seeing eye. In Raynaud's disease, the vasospastic elements of thrombo-angiitis obliterans, the vasoconstrictor and vasodilator effects of