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ARTICLE |

PATHOGENIC GAS-PRODUCING ANAEROBIC BACILLI IN CHRONIC ULCERS

MELVILLE H. MANSON, M.D.
Arch Surg. 1932;24(5):752-774. doi:10.1001/archsurg.1932.01160170039003.
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Report of Cases

Summary of Cases

Suggested Relationship Between Chronic Ulcers and Gas Gangrene

Technic

Isolation of Anaerobes

Pathogenicity

Differentiation of Organisms

Clinical Application

Results

Cases Harboring Anaerobes

Control Cultures

Ubiquity of Clostridium Welchii

Comment

Significance of Results

Status of Anaerobic Antitoxins

Summary

Two virulent cases of gas gangrene following amputation of extremities that were the site of chronic ulcers stimulated interest in this subject. Gas gangrene is usually the result of severe trauma with muscle destruction and a wound grossly contaminated with dirt and foreign bodies. The problem presented itself as to the origin of the gas bacillus infection in postoperative wounds, in which all the usual aseptic and antiseptic precautions had been employed, and the possible relationship of the ulcers to the development of the gas bacillus infection was suggested. This paper includes a report of two cases and a bacteriologic study of chronic ulcerating lesions with particular

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