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April 1933, Vol 26, No. 4 >
ARTICLE | April 1933

EFFECT OF ALKALIS ON EXPERIMENTAL PEPTIC ULCER

JACOB MEYER, M.D.; HENRY H. RUBIN, M.D.
Arch Surg. 1933;26(4):684-688. doi:10.1001/archsurg.1933.01170040147010.
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The use of alkalis in the treatment of peptic ulcer is based on the assumption that the complete neutralization of hydrochloric acid by the administration of alkalis renders gastric peptic digestion inactive, and the granulation tissue of the ulcer heals.

The purpose of the present study was to determine the effect of the administration of alkalis on experimental peptic ulcer as produced by Mann and Williamson.1 These observers were able to produce ulcers in dogs by surgical duodenal drainage; i. e., the junction of the pylorus and duodenum was severed and the duodenal end closed. The duodenojejunal angle was located, and the jejunum was followed down for a distance of from 10 to 15 cm., at which point it was transected. The proximal end of the jejunum was anastomosed into the terminal portion of the ileum from 20 to 30 cm. from the cecum by means of an end-to-side

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