In a previous study1 we found that the removal of the celiac ganglion resulted in a decided, persistent rise of tolerance in every instance. The dogs became more sensitive to insulin. A denervation of the liver did not produce a rise in tolerance. To analyze the mechanism of our previous results, the rôle of the suprarenal glands was investigated in the study to be reported here.
Elsewhere2 we summarized the literature on the effect of suprarenal denervation and of splanchnic section on sensitivity to insulin. It was reported uniformly that removal of the medulla, denervation of suprarenal glands or bilateral splanchnic section renders the animals more sensitive to insulin. The determination of hypersensitivity to insulin was only roughly quantitative, the criterion being whether convulsion occurred with a dose of insulin which prior to the operative procedure failed to cause convulsion. Regarding sugar tolerance before and after suprarenal denervation