The clinician has believed for many years that in some way acid is a factor in the production of peptic ulcer. Many facts tend to confirm this belief. The most important of these facts are the following: 1. The typical lesion that is called peptic ulcer occurs only in that portion of the gastro-intestinal tract that can be exposed to an acid medium. 2. Many patients with peptic ulcer have a so-called hyperacid condition. 3. A definite relationship exists between some of the symptoms of the condition, such as pain after meals, and the activities of the stomach, including its secretory function. 4. In many instances the taking of food that will act as a buffer against acid or of medicinal agents that will neutralize acid gives relief from pain.
Much of the recent experimental work on peptic ulcer also has tended to emphasize the great importance of acid as