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EXPERIMENTAL STAPHYLOCOCCIC SUPPURATIVE ARTHRITIS AND ITS TREATMENT WITH BACTERIOPHAGE

GEORGE ALBERT LAKE INGE, M.D., Sc.D. (Med.); JAMES WILLIAM TOUMEY JR., M.D., Sc.D. (Med.)
Arch Surg. 1935;31(4):642-661. doi:10.1001/archsurg.1935.01180160138012.
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Since d'Herelle's1 discovery in 1917 of the phenomenon to which he applied the term bacteriophagy an extensive literature on the subject has accumulated, an increasing part of which has been devoted to the therapeutic use of this biologic principle in clinical medicine. Perhaps because of the dramatic nature of the phenomenon in the test tube, perhaps because the imagination is so fired by a principle which was to rid the world of bacterial diseases, there has often been a great deal of overenthusiasm in the claims advanced for the therapeutic effects of bacteriophage. Such overenthusiasm, born for the most part of insufficient observation or loosely controlled experiments, has given rise among many serious clinicians to a skepticism which denies to bacteriophage any place in the realm of therapeutics. The misfortune of this situation is that a valuable biologic principle is denied a trial by the very men whose work

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