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LACTOGENIC SUBSTANCE IN THE HUMAN BREAST:  ITS USE IN EXPERIMENTAL STIMULATION OF MAMMARY SECRETION AND ITS ASSAY IN CASES OF CYSTIC DISEASE

CHARLES F. GESCHICKTER, M.D.; DEAN LEWIS, M.D.
Arch Surg. 1936;32(4):598-617. doi:10.1001/archsurg.1936.01180220024002.
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That there exists a relationship between the anterior lobe of the hypophysis and lactation has been shown by the work of Grüter and Stricker.1 Investigations which demonstrated the effect of extracts of the anterior lobe of the hypophysis on mammary secretion have been made by Corner,2 Nelson and Pfiffner,3 Gardner and Turner4 and Riddle, Bates and Dykshorn.5 These studies have shown that when the mammary glands of rats, guinea-pigs, rabbits and dogs have been stimulated by the injection of ovarian hormones, injections of extracts of the anterior lobe of the hypophysis may initiate secretory activity.

Purified lactogenic substances have been prepared from the anterior lobe of the hypophysis by Turner6 and his co-workers and by Riddle and his co-workers. The use of these extracts and the response of the crop of the pigeon as a method of bio-assay opened new fields for the investigation

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