Reports in the literature of the association of urinary calculi and diseases of the bone have been confined chiefly to the presentation of cases, and in some instances analyses of the chemical composition of the calculi have been given. Occasionally the presence of infection in the urinary tract has been noted when calculi developed during a long period of immobilization. The formation of urinary calculi under such circumstances is not a rare and unusual complication, and a few cases have been reported and discussed from the etiologic standpoint, but little thought has been given to the nature of the disease and its prevention.
The physiochemical reactions which aid or prevent the formation of urinary calculi have ceased to be matters for conjecture, and it is now recognized that a deficiency in vitamin A, infection in the urinary tract, urinary stasis, hyperparathyroidism, phosphaturia, oxaluria and excessive quantities of uric acid definitely