In 1924 Mason and Davidson published reports of experiments which directed attention to the toxic effect of fresh liver implanted in the peritoneal cavity. Later Ellis and Dragstedt1 (1930) repeated this work and came to the conclusion that the death of the animals in which liver had been placed in the peritoneal cavity was due to the severe peritonitis caused by an organism similar to Bacillus Welchii. Peritonitis did not occur when pieces of adult or fetal liver which had been autoclaved were introduced into the abdomens of dogs. According to these authors the infection came from the liver in which the bacteria persisted in a latent state until stimulated to activity by the asphyxia of the liver tissue.
Andrews and Hrdina2 repeated these experiments, as they did not believe that when animals died in so short a time (from twenty to twenty-four hours) death could be attributed