0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

PRODUCTION OF OSTEOSARCOMA IN A MOUSE BY THE INTRAMEDULLARY INJECTION OF 1,2-BENZPYRENE

A. BRUNSCHWIG, M.D.; A. D. BISSELL, M.D.
Arch Surg. 1938;36(1):53-60. doi:10.1001/archsurg.1938.01190190056004.
Text Size: A A A
Published online

Primary malignant neoplasms of bone have been produced experimentally by irradiation. Schürch1 induced an osteosarcoma in the mandible of a rabbit by the application of a radium needle directly to the cortical surface. Lüdin2 produced a chondrosarcoma in the tibia of a rabbit by repeated exposures to the roentgen rays (total dose, 8,000 roentgens). Schürch and Uehlinger1 produced three ossifying sarcomas of the femur in rabbits by intra-osseous injections of minute quantities of radium salts. Widespread ossifying metastases in the lungs, spleen, liver and lymph nodes were observed. In two other animals nonossifying fibrosarcomas of bone developed. Daels3 and Sabin, Doan and Forkner4 also produced fibrosarcoma of bone in animals by means of radioactive substances.

In Martland's5 series of patients who were poisoned by the prolonged ingestion of radioactive material, which accumulated in the skeleton, nonossifying fibrosarcomas of bone developed. These instances constitute experiments

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();