PRODUCTION OF EXPERIMENTAL TUMORS OF THE BRAIN WITH THE SHOPE RABBIT PAPILLOMA II

The gross characteristics of extradural and subdural growths produced by implantation of virus-induced cutaneous rabbit papilloma¹ and the reaction of the brain to such experimental tumors have been described briefly.² It was noted in a small series of implantations that the intracranial growths were essentially similar to those observed following implantation in other tissues of the host. The proliferating epithelium of the individual growths did not invade the adjacent nerve tissue, and the growths thus presented the picture of slowly expanding intracranial tumors. Histologic study showed that there was no glial reaction when implantation was extradural and a layer of meninges was interposed between the tumor and the brain. When, on the other hand, the tumor was implanted subdurally, thus coming into more direct contact with the parenchyma of the brain, there was always proliferation of astrocytes with formation of numerous fibers, which were attached to the tumor