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May 1940, Vol 40, No. 5 >
ARTICLE | May 1940

INFLUENCE OF BONE ASH ON THE REPAIR OF BONE

J. DEWEY BISGARD, M.D.; HAROLD H. MACUMBER, M.D.
Arch Surg. 1940;40(5):984-987. doi:10.1001/archsurg.1940.04080040166015.
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In a previous publication1 there was presented experimental evidence that bone ash aided ossification. In the reported experiments transplants of osteogenic tissue were cultured in the anterior chamber of the eye in a medium saturated with bone ash. It was suggested that the minerals used in the formation of bone exist in bone and in bone ash in a physicochemical form particularly suitable for use in the process of ossification.

To examine this evidence further, the influence of bone ash on the repair of fractures was investigated in a series of 11 rabbits. In the original series of 24, 13 were lost by death or infection.

METHOD  In each animal equal segments were removed from the shaft of each radius in total block resection, and to discourage repair small bits of costal cartilage were placed in the defects between the fragments. In addition to cartilage, bone ash derived from

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