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SERUM PROTEINS AND WOUND HEALING

HARRY KOSTER, M.D.; ARTHUR SHAPIRO, M.D.
Arch Surg. 1940;41(3):723-729. doi:10.1001/archsurg.1940.01210030157010.
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Although many studies of serum proteins in the human being in the normal state and in various pathologic conditions have been published,1 apparently no studies of serum protein concentration in relation to wound healing have been reported.

We have studied the concentrations of total protein, albumin and globulin, the albumin-globulin ratio and the calculated protein oncotic pressure of the serum of 58 patients in the postoperative state whose wounds were carefully observed. In the cases of 17 who had hernioplasties with clean wounds (table 1) the determinations were done from one to ten days after operation (average four days). In the cases of 23 who had abdominal operations with clean wounds (table 2) the determinations were done from one to twenty-two days postoperatively (average eight days). In the cases of 16 who had abdominal wounds complicated by deep infections extending below the fascia (table 3) the determinations were done

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