Carcinoma arising in a chronic osteomyelitic sinus tract has been reported sporadically for more than a hundred years and with somewhat greater frequency within the last decade. Nevertheless, the increasing incidence of chronic osteomyelitis that may be expected as a consequence of the war justifies directing attention to a complication that is by no means generally appreciated. This consideration and the fact that there are few reports of metastasis from carcinoma of an osteomyelitic sinus tract have prompted us to submit 2 cases and to review the literature.
The first case of this type of carcinoma appears to have been reported by Hawkins,1 of London, England, in 1835, under the title "Cases of Warty Tumors in Cicatrices." Dittrich2 in 1847 recorded the next case, in which the tibia was involved. Thigh amputation was performed, and the diagnosis of carcinoma was confirmed by Rokitansky. Between 1851 and 1891 the