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Arch Surg. 1942;44(1):129-138. doi:10.1001/archsurg.1942.01210190132015.
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Capillary permeability and inflammation have been studied recently in the rabbit under varying experimental conditions. Observations on the localization and the concentration of intravenously injected trypan blue in the skin of the normal animal have shown that this dye localizes and concentrates only during a specific interval following the local application of xylene.1 This interval is not determined by either the presence or the absence of edema and hyperemia. Furthermore, the time in which the greatest number of leukocytes localize in the xylene-treated areas of the skin follows by several hours the localization and the concentration of the dye.1b

Materials such as vaccine virus, india ink, antitoxin and staphylococci when given intravenously localize and concentrate in areas of inflammation in a manner similar to that of trypan blue.2 Both capillary permeability and the localization of leukocytes in areas of injury are affected by alcohol, by certain anesthetics


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