The purpose of this study is to determine the effect of large doses of sodium sulfadiazine (the monohydrate sodium salt of 2-[paraaminobenzenesulfonamido]-pyrimidine) given subcutaneously to rabbits with wounds inoculated with a measured amount of a culture of beta hemolytic streptococcus of known virulence.
Rabbits weighing from 2,200 to 3,800 Gm. were used. Soluble pentobarbital (0.80 cc. of a solution containing 0.06 Gm. of pentobarbital per cubic centimeter) administered in an aural vein supplemented by light open drop ether was used to induce anesthesia for all operations. Aseptic technic was used throughout. A longitudinal incision 2 cm. long was made 1 cm. to the left of the midline posteriorly and 2 cm. inferior to the lowest rib. The skin, the subcutaneous tissue and the muscle sheath were incised. By means of a brass cork borer with a diameter of 1 cm., a segment of sacrospinalis muscle 2 cm. in depth