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ARTICLE |

PHYSIOLOGY OF GASTRIC SECRETION, PARTICULARLY AS RELATED TO THE ULCER PROBLEM

M. J. SCHIFFRIN, Ph.D.; A. C. IVY, M.D., Ph.D.
Arch Surg. 1942;44(3):399-413. doi:10.1001/archsurg.1942.01210210003001.
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The purpose of this paper is to present a brief review of certain aspects of the physiology of gastric secretion with the idea of indicating their actual or possible relation to the ulcer problem. No attempt will be made to list and evaluate the numerous theories of the genesis of ulcer.

The matter will be divided into three main sections. The first will deal with the normal physiology of stimulation and inhibition of gastric secretion and its composition and will contain a note regarding the normal control of gastric acidity. The second will deal with the abnormal factors which influence gastric secretion. The third will deal with gastric secretion as affected by ulcer and the relation of gastric juice to the causation of ulcer.

I. THE NORMAL PHYSIOLOGY OF GASTRIC SECRETION 

The Interdigestive or Continuous Secretion, or the Interdigestive Period of Secretion.  —The empty or fasting stomach usually secretes a

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