Exhaustive efforts to find measurable abnormalities of the inorganic constituents, other than of iodine, in the blood of patients with hyperthyroidism have been fruitless. The literature on these endeavors was well summarized by Maddock, Pedersen and Coller1 and by Bartels.2 It is not sufficiently appreciated with what care the constancy of concentrations of the electrolytes, particularly of the cations, is maintained. Yet all who have particular interest in this field must have felt the urgency of the belief that something measurable by biochemical methods must be importantly disturbed in patients with thyrotoxicosis and have wished, to quote Maddock, "we only knew what to measure." It is my contention that investigators have been analyzing the wrong body fluid, as will presently be shown.
SERIAL DETERMINATIONS OF THE CARBON DIOXIDE—COMBINING POWER OF PLASMA
My own interest in the acid-base equilibrium of the patient with hyperthyroidism was aroused in 1930 in