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Arch Surg. 1942;45(2):316-322. doi:10.1001/archsurg.1942.01220020136010.
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Carcinoma of the thyroid has been the subject of numerous excellent contributions in which its various aspects and phases have been fully discussed. Information regarding the pathologic nature, the diagnosis and the treatment of this type of tumor has been greatly increased. Nevertheless, there remain many problems to be solved and large and small gaps in the knowledge of it to be filled.

A case recently observed at this hospital has drawn our attention to the well known, but curious and unexplained, fact that carcinoma of the thyroid is exceedingly rare with diffuse hyperplasia of this gland.

Coller1 found a gland hyperplastic only once among 90 cases of thyroid carcinoma. Pemberton2 observed diffuse hyperplasia in 10 instances of 774 cases of thyroid cancer, and Friedell,3 in 12 among 412 cases. Four cases of carcinoma in a hyperplastic gland were mentioned by Clute and Warren.4 No such


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