The purpose of this paper is to report a series of experiments with animals carried out in order to evaluate the effectiveness of the local application of certain of the newer chemotherapeutic agents in fresh traumatic wounds contaminated with the species of clostridia commonly associated with clinical gas gangrene in human beings.
While there are already considerable data along these lines, the results of the experiments reported in the literature have not been uniform, and there are differences of opinion among various observers as to the merit of chemotherapy in relation to the prevention and the treatment of these infections.
REVIEW OF THE LITERATURE
The first article dealing with the use of sulfonamide compounds in the treatment of gas gangrene in experimental animals was that of Domagk1 in 1937. He produced gas gangrene in mice by the intramuscular injection of Clostridium septicum and treated the animals with certain of