Changes attributed to sulfonamide compounds have been reported by other investigators.1 We2 recently reported lesions in dogs produced by sodium sulfadiazine (the monohydrate sodium salt of 2-[paraaminobenzenesulfonamido]-pyrimidine), and similar lesions in the kidney of man have been recorded.3
To study the effects of sulfadiazine and of the combination of sulfadiazine and ether anesthesia on the liver, kidney and reticuloendothelial system, the following procedures were employed.
Ten mongrel dogs each weighing from 6.2 to 16.4 Kg. were used in the first experiment. Blood was withdrawn for erythrocyte and leukocyte counts, and differential leukocyte and platelet counts were made on blood smears. Determinations of hemoglobin, hematocrit reading, icterus index and prothrombin were made. The urine was examined microscopically; the heat-acid test for the presence of proteins was done, and the acidity or alkalinity was determined with litmus paper.With the animal under anesthesia induced with sodium pentobarbital, administered