Arch Surg. 1943;46(5):666-672. doi:10.1001/archsurg.1943.01220110082015.
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Monday, the second day of November 1846, dawned cold and cloudy in Boston and the cheerless sky was leaden throughout the day. Darkness was upon the town before half after five and the cold wind began to blow from the bay, with the evening flow of the tide. Few people walked about the quiet streets, and the clatter of an occasional carriage seemed to intensify the unpleasantness of the weather by raising dismal echoes ordinarily muffled in the bustle of the busy thoroughfares.

In Summer Street, the cheery glow of parlor lights meant that most of the good dwellers in that fine neighborhood were staying indoors for the evening, but at no. 27, Dr. Henry Jacob Bigelow bundled into his great coat and ventured forth to make a call. He walked up to Washington Street, where a north turn and a few more steps brought him to Bromfield Street, turned


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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