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INFLUENCE OF HEPATIC FUNCTION ON METABOLISM OF VITAMIN A

KARL A. MEYER, M.D.; FREDERICK STEIGMANN, M.D.; HANS POPPER, M.D.; WILLIAM H. WALTERS, M.D.
Arch Surg. 1943;47(1):26-43. doi:10.1001/archsurg.1943.01220130029005.
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Many facts indicate an influence of the liver on the metabolism of vitamin A. In acute1 and chronic2 hepatic disease the vitamin A content of the blood is low. Night blindness due to deficiency of vitamin A has been reported in acute hepatitis3 and in cirrhosis even without jaundice.4 The vitamin A content of the liver is low in chronic hepatitides (cirrhoses)5 and variable in acute hepatitis and in catarrhal or arsphenamine jaundice.6 The histologic distribution of vitamin A in the liver is considerably changed by damage to the liver.7 Several factors have been mentioned to explain the foregoing observations, such as: (1) faulty absorption of vitamin A and especially of carotene from the intestinal tract8; (2) inability of the liver to store vitamin A, although more emphasis is laid on alterations of the reticuloendothelial system than on damage to the hepatic

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