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ROLE OF THE CHEMICAL LABORATORY IN DIAGNOSIS OF NEOPLASTIC DISEASES OF BONE

HELEN QUINCY WOODARD, Ph.D.
Arch Surg. 1943;47(4):368-383. doi:10.1001/archsurg.1943.01220160052008.
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Much confusion has existed regarding the significance of changes in the chemical composition of the blood and urine of patients with tumors of bone. This confusion arises mainly from the fact that the chemical changes are nonspecific, several diseases of unrelated cause being capable of causing the same chemical abnormality. If the mechanism of the chemical changes is understood, a consideration of the laboratory data will often establish a diagnosis which could not be made by clinical observation alone. It is the purpose of the present paper to consider the conditions under which this can be done. Only such chemical tests as can be made in the average well equipped hospital laboratory will be considered. For a few patients a diagnosis can be established only by means of the highly specialized procedures employed in metabolism wards, but these are outside the scope of the present paper. Non-neoplastic diseases of the

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