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ADMINISTRATION OF SUCCINYLSULFATHIAZOLE BEFORE AND AFTER HEMORRHOIDECTOMY

LEO L. LEVERIDGE
Arch Surg. 1944;48(5):366-371. doi:10.1001/archsurg.1944.01230010377002.
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Hemorrhoidectomy is an elective operative procedure, traditionally performed in a contaminated field. The presence of large numbers of potentially pathogenic bacteria in this operative site, and flowing over the healing wounds postoperatively, has always had to be accepted as unavoidable. With recent developments of chemotherapy, means appear now within reach to alter these conditions.

Two drugs, sulfanilylguanidine and succinylsulfathiazole,1 have been reported to decrease the bacterial flora in the gastrointestinal tract, apparently without excessive systemic absorption. The newer drug, succinylsulfathiazole,2 appears to be less toxic and yet to be as effective as sulfanilylguanidine, with the additional advantage of being effectual in the presence of ulcerating lesions of the bowel.3

CHEMISTRY OF SUCCINYLSULFATHIAZOLE  Structurally, succinylsulfathiazole is a succinic acid derivative of sulfathiazole. It is relatively strongly acid in reaction. Its solubility in water is low, 0.070 Gm. dissolving in 100 cc. of water at 37 C. However, the

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