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October 1944, Vol 49, No. 4 >
ARTICLE | October 1944

EFFECT OF TOPICAL APPLICATION OF VITAMINS AND SOME OTHER CHEMICALS ON THE HEALING OF WOUNDS

ROBERT H. WILLIAMS, M.D.; GROSVENOR W. BISSELL, M.D.
Arch Surg. 1944;49(4):225-227. doi:10.1001/archsurg.1944.01230020233002.
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Many studies have been reported of the effect of various substances in promoting the healing of wounds. Most of these investigations have dealt with antibacterial drugs, but some have dealt with dietary measures which tend to improve the condition of the subject as a whole and in turn increase the rate of healing of wounds.1 Deficiency in the body of proteins,2 vitamins A and Dla and vitamins C3 impairs the rate of healing of wounds.

A number of local factors influence healing. Messer and McClellan4 found that wounds benefited more from an alkaline pH than from an acid one. Several investigators5 reported that the local application of concentrated urea is of distinct aid in promoting healing of wounds, particularly for removing debris and necrotic tissues. However, this therapy is often associated with marked discomfort. Compounds containing the sulfhydryl radical6 stimulate growth of

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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AAM 2010;304:1493-1495.
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BMJ 2010;341:c5893-c1494.
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