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ARTICLE |

PENICILLIN IN THE TREATMENT OF CHRONIC OSTEOMYELITIS:  A PRELIMINARY REPORT

JOSEPH BUCHMAN, M.D.; JOHN E. BLAIR, Ph.D.
Arch Surg. 1945;51(2):81-92. doi:10.1001/archsurg.1945.01230040086003.
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The history of the treatment of chronic osteomyelitis is replete with many rebuffs to the suffering victims, despite the application of many new procedures and drugs and serums which have been developed in recent decades. Notwithstanding the fact that these new approaches have produced spectacular results in the treatment of other types of infections, they have been found wanting in the treatment of chronic osteomyelitis. These failures are due to the inherent nature of the chronic osteomyelitic lesion. Many hopes, raised high with the advent of every new therapeutic agent, have met with disappointment due to the lack of appreciation of the differences existing between the chronic osteomyelitic lesion and other lesions and the specialized problems involved in the cure of the disease under consideration

Rational therapy can be administered only when the pathologic character of the involvement is appreciated. Briefly, the chronic osteomyelitic lesion presents a diseased bone which

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