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LEIOMYOSARCOMA OF THE UTERUS WITH METASTASIS TO THE FEMUR:  REPORT OF A CASE AND REVIEW OF THE LITERATURE

WALLACE S. BROOKE, M.D.; J. R. THOMASON, M.D.
Arch Surg. 1945;51(2):120-124. doi:10.1001/archsurg.1945.01230040125008.
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Sarcoma of the uterus was first described by Virchow in 1860. Since then, many isolated cases and collected series of cases have been reported. In most cases the sarcoma is discovered unexpectedly as a result of removing a fibroid tumor, and thus these cases are usually reported as a percentage of cases of uterine fibroids examined pathologically.

Opinion differs as to whether malignant myomas are malignant from the beginning or whether they represent a malignant change in an originally benign tumor. Ewing1 said that these tumors are malignant from the start. Masson2 took a different viewpoint and felt that they may originate in fibromyomas or in adjacent connective, muscle or endometrial tissue.

The reported incidence of uterine sarcoma varies from 0.2 to 10 per cent, with the majority of observers favoring an incidence of 0.5 to 2 per cent. Vogt3 collected reports of 72,116 cases of myoma

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