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PROGRESS IN ORTHOPEDIC SURGERY FOR 1944 A Review Prepared by an Editorial Board of the American Academy of Orthopaedic Surgeons XVIII. Infections of Bones and Joints Exclusive of Tuberculosis

Arch Surg. 1946;52(3):327-336. doi:10.1001/archsurg.1946.01230050332006.
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AS HAS been true in all the years of the war, the literature for 1944 contained relatively few articles on osteomyelitis excepting those dealing primarily with reports of cases in which penicillin therapy and chemotherapy were used. When a new antibiotic is introduced there is always a flood of such reports, with few articles that rationalize the changes that are necessary to allow the new drug or procedure to take its proper place in the over-all picture of the disease under discussion. Certainly penicillin is a valuable adjunct in the treatment of osteomyelitis, and its presence makes necessary a reevaluation of previous ideas in regard to treatment of this disease. The antibiotic value of penicillin has been established. Studies are now needed to determine its side actions on the reticuloendothelial tissues, the hemopoietic system, the glands of internal secretion and the other factors associated with the response of the body


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