Arch Surg. 1947;55(1):58-63. doi:10.1001/archsurg.1947.01230080061005.
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THIS report deals with regional infiltration with penicillin, a method of therapy that has demonstrated its value in localized infections.

Florey1 in his original 15 cases in which treatment was with penicillin suggested the possibilities of local application of penicillin. Fraser2 and Flippen3 injected penicillin into the cavities of soft tissue abscesses after aspiration of the purulent exudate. Several writers4 have recommended the topical use of penicillin in the form of creams or solutions. Cutler and Sandusky5 advocated a combination of penicillin powder and lyophilized human plasma. There are many reports6 of the use of penicillin in combination with surgical débridement and its instillation into closed cavities. Peck7 presented 15 cases in which penicillin solution was injected directly into the necrotic tissues or sinuses of infected areas in diabetic patients with good results. He utilized a solution of penicillin in isotonic sodium chloride


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