August 1947, Vol 55, No. 2 >

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ARTICLE | August 1947

EFFECT OF ENTEROGASTRONE ON MANN-WILLIAMSON ULCERS IN DOGS

H. C. SALTZSTEIN, M.D.; DAVID J. SANDWEISS, M.D.; JOHN M. HAMMER, M.D.; EDWARD J. HILL, M.D.; HENRY J. VANDENBERG, M.D.

Arch Surg. 1947;55(2):125-129. doi:10.1001/archsurg.1947.01230080130002.

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ABSTRACT

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THIS study has been conducted to evaluate the effect of orally administered enterogastrone on a series of dogs in which jejunal ulcer had been produced by the Mann-Williamson operation. Previous study of a similar nature by others¹ has shown that enterogastrone exerts a prophylactic, therapeutic and "immunizing" effect on the experimental Mann-Williamson ulcer when administered parenterally and orally. Recently Ivy and associates² reported a beneficial effect from enterogastrone in preventing recurrence of ulcer in the treatment of patients.

Enterogastrone is a hormone prepared from small intestine mucosa and exerts an inhibiting (or chalonic) effect on gastric motility and secretion. First prepared by Kosaka and Lim³ from the mucosa of the small intestine of dogs, it was subsequently prepared in purer form by Gray, Bradley and Ivy⁴ from the mucosa of small intestine of hogs.

METHOD The routine Mann-Williamson operation, as reported in a separate publication,⁵

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SALTZSTEIN HC, SANDWEISS DJ, HAMMER JM, HILL EJ, VANDENBERG HJ, Jr.. EFFECT OF ENTEROGASTRONE ON MANN-WILLIAMSON ULCERS IN DOGS. Arch Surg. 1947;55(2):125-129. doi:10.1001/archsurg.1947.01230080130002.

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