THE PRESENT study was conducted for the purpose of determining the effect of vagotomy on experimentally produced Mann-Williamson peptic ulcers in dogs. Although there are other methods of experimentally producing peptic ulcers, the Mann-Williamson operation was chosen because the jejunal ulcer which ensues closely simulates the postoperative jejunal ulcer seen in man. In 98 to 100 per cent of control animals jejunal ulcers develop after the operation.
METHOD OF STUDY
The Mann-Williamson operation was performed in the standard manner, viz: transection at the pylorus, closure of the duodenal stump, transection of the jejunum 4 inches (10.1 cm.) beyond Trietz' ligament, end to side gastrojejunostomy using the distal cut portion of the jejunum and side to side jejunoileostomy anastomosing the proximal cut portion of the jejunum to the ileum 25 cm. above the ileocecal valve (fig. 1). This short-circuits the bile, pancreatic juice and duodenal secretions into the terminal ileum. Ulcers