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Arch Surg. 1948;57(3):385-390. doi:10.1001/archsurg.1948.01240020391009.
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DURING the sixteen months from October 1946 through January 1948, 12 women under care at the Henry Ford Hospital for breast cancer, recurrent after radical operation, were given testosterone propionate1 and the resulting effects closely watched. Individual doses were mostly 150 mg. Aggregate total doses were from 450 to 6,225 mg. Injections were intramuscular in alternate buttocks. Given slowly, they have not produced pain, soreness or any late untoward local reactions. Only in the first 2 patients treated were there objectionable general reactions to the drug, and those were the result of unnecessary abruptness with large initial doses. There have been slight masculinizing effects in 3 patients, principally of the voice, none sufficient to create a problem. Of the 12 patients treated, 6 have died, but only 1 of the entire group failed to show some observable beneficial clinical response. In 6 of the 12, clinical improvement was striking,


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