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August 1949, Vol 59, No. 2 >
ARTICLE | August 1949

NEUROFIBROMATOSIS AND PSEUDARTHROSIS:  Report of a Case

JULIAN E. JACOBS, M.D.; PAUL KIMMELSTIEL, M.D.; KEARNS R. THOMPSON, M.D.
Arch Surg. 1949;59(2):232-239. doi:10.1001/archsurg.1949.01240040237006.
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SINCE Barber's1 and Ducroquet'slb publications in 1939, bowing of the legs, fractures and pseudarthrosis have been accepted as one of the manifestations of von Recklinghausen's neurofibromatosis. Clinically and roentgenologically the lesions are clearly described, but the morphologic changes taking place in the skeletal system are as yet not completely understood. The first, and apparently only, microscopic examination of tissue in pseudarthrosis connected with neurofibromatosis was published by Green2 in 1943. The following report of a case of neurofibromatosis also includes the microscopic observations on tissues removed from the area of pseudarthrosis, essentially confirming those described by Green, but in addition it presents unusual features which, to our knowledge, have not been recorded in the past.

REPORT OF A CASE  B. H., a white girl aged 3 years, 9 months, was admitted to the North Carolina Orthopedic Hospital on Jan. 28, 1947, because of nonunion of fracture of

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