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ADENOMATOUS GOITERS WITH AND WITHOUT HYPERTHYROIDISM:  Some Aspects of the Relationship of the Microscopic Appearance to Hyperthyroidism

JAMES R. JOHNSON, M.D.
Arch Surg. 1949;59(5):1088-1099. doi:10.1001/archsurg.1949.01240041098010.
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THE DATA presented herein are drawn from a larger study. The general purpose of the complete study was to determine if possible whether any histologic data can be found on the adenomatous nodules of the thyroid gland which would correlate with the presence of thyrotoxicosis in a patient. In short, it was decided to inquire again into the question of whether the pathologist can predict the presence of toxic phenomena in the patient from examination of the nodular or adenomatous tissue from the thyroid gland.

A nodule of the thyroid gland may be defined as a more or less encapsulated mass of thyroid tissue which may or may not be different from the surrounding thyroid tissue.

The term "nodular goiter" is used frequently by pathologists and surgeons as a synonym for adenomatous goiter. Although it is true that adenomatous goiters are nodular, thyroid nodules are not necessarily adenomas. Thyroid nodules

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