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ACTION OF VARIOUS PHARMACOLOGIC AND OTHER AGENTS ON THE COLON OF MAN

WILLIAM J. GRACE, M.D.; CRANSTON W. HOLMAN, M.D.; STEWART WOLF, M.D.; HAROLD G. WOLFF, M.D.
AMA Arch Surg. 1950;61(6):1036-1051. doi:10.1001/archsurg.1950.01250021046005.
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OPPORTUNITIES to assess directly the effects of pharmacologic agents on large segments of exposed, intact human colon in the unanesthetized state have been rare. Such studies have been reported by Puestow1 and Weeks,2 and recently a new opportunity to study directly the appearance and function of the colon in four human subjects with fistulas became available. Previous reports have concerned themselves chiefly with motility functions. The present communication is based not only on observations of motility but also on a study of alterations in color, degree of engorgement and fragility of the mucous membrane.

SUBJECTS  Subject A was a 26 year old mechanic who had had chronic ulcerative colitis for six years. An ileostomy had been performed two years previously. Shortly after the ileostomy there occurred a large prolapse of ascending colon and cecum through an old cecostomy wound. The prolapsed area measured 7 by 2½ inches (18

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