May 1951, Vol 62, No. 5 >

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ARTICLE | May 1951

EFFECTS OF VAGUS SECTION WITH SUBTOTAL GASTRECTOMY AND DIVERSION OF DUODENAL SECRETIONS INTO THE TERMINAl PORTION OF THE ILEUM ON ULCER DEVELOPMENT

JAMES V. OLIVER, M.D.

AMA Arch Surg. 1951;62(5):649-657. doi:10.1001/archsurg.1951.01250030659005.

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IT HAS previously been shown that bilateral section of the vagi did not prevent the development of the jejunal ulcer in the Mann-Williamson dog.¹ It has also been demonstrated experimentally that the presence of gastric secretion is the important factor in the development of the stomal ulcer after a Mann-Williamson operation has been performed, in so far as no ulcer will develop if all the stomach has been removed, whereas a subtotal gastrectomy leaving 25 per cent of the stomach, followed by diversion of the duodenal secretions into the terminal portion of the ileum, will result in a high incidence of stomal ulcer.²

Inasmuch as chronic ulcers are produced experimentally by various surgical procedures which alter the normal gastrointestinal anatomy and physiology,³ it becomes apparent that an operative procedure which would protect an animal against the development of such an experimentally induced chronic stomal ulcer would have

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OLIVER JV. EFFECTS OF VAGUS SECTION WITH SUBTOTAL GASTRECTOMY AND DIVERSION OF DUODENAL SECRETIONS INTO THE TERMINAl PORTION OF THE ILEUM ON ULCER DEVELOPMENT. AMA Arch Surg. 1951;62(5):649-657. doi:10.1001/archsurg.1951.01250030659005.

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EFFECTS OF VAGUS SECTION WITH SUBTOTAL GASTRECTOMY AND DIVERSION OF DUODENAL SECRETIONS INTO THE TERMINAl PORTION OF THE ILEUM ON ULCER DEVELOPMENT

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