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CONSIDERATION OF THE LETHAL FACTORS IN ACUTE PANCREATITIS

VINTON E. SILER, M.D.; JOHN H. WULSIN, M.D.
AMA Arch Surg. 1951;63(4):496-504. doi:10.1001/archsurg.1951.01250040506010.
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IN THE 10-year period 1941-1950 inclusive, there were 164 cases of admission for acute pancreatitis to the Cincinnati General Hospital. In each case the diagnosis was based on at least one of the following criteria: (1) a consistent clinical history in conjunction with increased serum amylase; (2) surgical observation, and (3) postmortem examination. In each case acute pancreatitis was the major factor in the illness.

The disease acute pancreatitis falls into three general clinicopathological subtypes, as indicated in a previous report:1 1. Acute interstitial (edematous) pancreatitis, usually self-limiting and rarely fatal, is identified at operation or at necropsy by induration and swelling of the pancreas without softening or hemorrhage. In the absence of anatomical verification, a patient with acute pancreatitis is arbitrarily placed in this group if the clinical course is benign and if there is no evidence of hemorrhage, necrosis, or suppuration in and about the pancreas. One

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