0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

VOLEMIC SUBSTANCES FOR REPLACEMENT OF BLOOD

JESSE L. BOLLMAN, M.D.; ROBERT C. KNUTSON, M.D.; JOHN S. LUNDY, M.D.
AMA Arch Surg. 1951;63(6):718-727. doi:10.1001/archsurg.1951.01250040734002.
Text Size: A A A
Published online

SOLUTIONS of macromolecular substances have been used for the purpose of expanding the volume of plasma by virtue of their colloidal osmotic activity while they remain in the blood. Because of the large size of their molecules, their diffusion from the blood is correspondingly reduced and their colloidal effectiveness prolonged. It is obvious that such substances do diffuse rather rapidly into the extravascular fluids and some are sequestered in specific tissue spaces. The rapid decline of their concentration in the blood after intravenous injection indicates that considerable portions have left the blood within a few minutes. Grotte, Knutson and Bollman1 found that dextran injected intravenously rapidly appeared in the lymph and that the colloidal osmotic gradient between the dextran in the blood and that in the extravascular fluids appear to be rapidly dissipated. The clinical effectiveness of these substances,2 however, appears to be more prolonged than would be

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();