IN AN EARLIER experiment1 we demonstrated the efficacy of gelatin sponge in controlling local bleeding in the presence of the coagulation defect produced by controlled heparin and bishydroxycoumarin (dicumarol®) therapy. We had the impression that the fine mesh of interstices in gelatin sponge was responsible for the hemostasis, since the sponge was effective regardless of whether the fibrinogen phase or the prothrombin phase of coagulation was altered.
In the present experiment we have produced a hemorrhagic syndrome in dogs with large doses of total body x-irradiation in order to test the effectiveness of gelatin sponge in controlling local bleeding in the presence of the complex coagulation defect due to irradiation.
Sixteen mongrel dogs weighing from 6 to 9 kg. were used in this experiment. Dogs were dewormed and one week later subjected to total body irradiation,2 350 to 400 r, while under intravenous pentobarbital sodium anesthesia.