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EFFECTS OF DEXTRAN AND OF POLYVINYLPYRROLIDONE ADMINISTRATION ON LIVER FUNCTION IN MAN

JOHN G. REINHOLD, Ph.D.; A. J. VON FRIJTAG DRABBE, B.S.; MICHAEL NEWTON, M.D.; JOHN THOMAS, M.D.
AMA Arch Surg. 1952;65(5):706-713. doi:10.1001/archsurg.1952.01260020698009.
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THE USE of polyvinylpyrrolidone (PVP)1 and of dextran2 has been proposed for increasing the volume of plasma after hemorrhage and for the treatment of shock. Earlier experience with acacia used for this purpose indicated that it impaired liver function.3 In addition, the use of acacia depressed the formation of plasma protein,4 possibly because of its action on the liver. Although dextran and polyvinylpyrrolidone have been used extensively in foreign clinics, there is little specific information concerning possible ill effects on the liver function of man. Bohmansson and co-workers have made some studies of dextran, using for this purpose bile pigment, hippuric acid, and phosphatase determinations. We have extended these studies by means of other liver function tests, including several generally considered to be more sensitive than those used by these workers, and. in addition, have made similar studies of polyvinylpyrrolidone.

METHOD  The patients studied were those

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