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AMA Arch Surg. 1952;65(5):770-773. doi:10.1001/archsurg.1952.01260020762015.
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HYALURONIDASE has been shown to increase the rate of spread of fluid injected into subcutaneous tissues,1 and thereby accelerate absorption of such fluids. Its action depends on the lysis of hyaluronic acid, the cementing agent in the intercellular ground substance, so that more surface area of cellular membrane is made available for equilibration and absorption. However, no quantitative studies have been reported on the effect of hyaluronidase under conditions of clinical use. I have already studied the apparent absorption rates of solutions commonly used for subcutaneous injection in clinical practice2 which have served as controls for the present studies, designed to determine the effect of hyaluronidase, utilizing the same clinical technique.

METHODS  Isotonic (0.9%) sodium chloride solution and 5% glucose in water were injected subcutaneously in the thighs of eight patients who were in good clinical condition and who showed no evidence of dehydration or electrolyte imbalance. The


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