BECAUSE there appears to be disagreement on the question of how frequently carcinoma occurs in nontoxic nodular goiter,1 it seemed pertinent to analyze our experience with such cases occurring in an area in which goiter is not endemic.
This report is based upon an analysis of 200 consecutive cases of thyroid disease in which operation was performed at the Wadsworth Hospital, Veterans Administration Center, Los Angeles, and at St. John's Hospital, Santa Monica, Calif., from 1946 to 1952. The patients were adults whose ages ranged from 22 to 82 years at the time of operation (Table 1). Of the patients, 83 (41.5%) were women and 117 (58.5%) were men (Table 2). The high percentage of men in this series was due to the preponderantly male population of the Veterans Administration Hospital. Only 20% of the patients from the Wadsworth Hospital were women, while 86% of those operated on at