RECENTLY, we gave a preliminary report1 concerning the effects of methantheline (banthine®) bromide on the neuromuscular mechanisms of the urinary tract and indicated some useful therapeutic applications of this compound. It was also noted that further uses for methantheline bromide in urological disturbances were being investigated and would be reported when experimental data permitted definite conclusions.
In the present paper the action of methantheline bromide in patients with a variety of clinical disturbances will be discussed. These entities and the results of treatment will be described separately.
Methantheline bromide is a quaternary ammonium derivative,2 β-diethylaminoethyl-9-xanthenecarboxylate methobromide, which has been found to block transmission of nerve impulses through autonomic ganglia as well as at postganglionic cholinergic nerve endings.3 The drug is effective both orally and parenterally and has demonstrated no harmful side-effects.1
I. NEUROGENIC ENURESIS
Before discussing the effect of methantheline bromide in neurogenic enuresis, it would