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June 1953, Vol 66, No. 6 >
ARTICLE | June 1953

USE OF DEXTRAN IN CONTROL OF SHOCK RESULTING FROM WAR WOUNDS

WILLIAM H. AMSPACHER; ANTHONY R. CURRERI, M.D.
AMA Arch Surg. 1953;66(6):730-740. doi:10.1001/archsurg.1953.01260030750004.
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THIS STUDY was undertaken to determine the effectiveness of dextran, one of the plasma expanders, in controlling wound shock seen in battle casualties. During the past several years, a very extensive research program has been pursued in both military and civilian medical centers for the purpose of evaluating the various plasma expanders. Much of this research has been supported by the United States Army Surgeon General's Research and Development Board. The results of the investigations are summarized by Gropper1 and others in a collective review and will not be reported in detail. Suffice it to say that almost all investigators have found dextran, particularly Expandex, the product of the Commercial Solvents Corporation, to be safe and effective in the treatment of traumatic and surgical shock. However, most surgeons who have had experience in the treatment of fresh war wounds believe that there may be a difference in the response

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