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LOCALIZATION OF RADIOACTIVITY IN REGIONAL LYMPH NODES

HAROLD F. BERG, M.D.; WILLIAM M. CHRISTOPHERSEN, M.D.; AVROM M. ISAACS, M.D.; J. RAY BRYANT, M.D.
AMA Arch Surg. 1953;67(2):228-243. doi:10.1001/archsurg.1953.01260040233011.
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PROBLEM  THE DIAGNOSIS of an inoperable carcinoma with regional metastases often leaves the surgeon with little to offer the patient.1 Radiation therapy is resorted to, but this method has definite well-known limitations. In an effort to overcome the limitation of conventional radiation therapy, we attempted to utilize radioisotopes to localize radiation to the tumor and its regional metastases. This method utilizes the ionizing effect of the isotope as the source of radiation. A colloidal solution of radioactive element is injected into the tumor or organ involved. The colloidal particles are then apparently engulfed by phagocytes and carried through the lymphatics to the regional lymph nodes.2 If the amount of radioactivity deposited in the tumor and the lymph nodes is sufficient to deliver effective radiation, a certain degree of palliation should be anticipated.Two organs, the lung and the urinary bladder, were utilized in these experiments. The method can

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