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Gunther W. Nagel, M.D.
AMA Arch Surg. 1953;67(5):629-631. doi:10.1001/archsurg.1953.01260040640001.
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THE MASS of both clinical and experimental data dealing with the ulcer problem has become so vast that an occasional brief historical review is indicated if present procedures are to be evaluated properly.

In spite of an almost continuous introduction of new drugs, most internists will agree that patients with ulcers today may be temporarily healed, some permanently controlled, but none permanently cured by medical means. Indeed, many internists are becoming more surgically minded as to the problem of peptic ulcer.

That subtotal gastric resection continues to find a place in the treatment of peptic ulceration is evidenced by the large number of articles in the current surgical journals dealing with this method of treatment.

Whereas many factors undoubtedly play a part in the genesis of ulcer, it is now generally agreed that hypersecretion of acid-pepsin digestive juices is one of the essential factors. Both the medical and surgical treatment


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