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INTESTINAL ANTISEPSIS WITH OXYTETRACYCLINE (TERRAMYCIN) AND NEOMYCIN:  A Comparative Study

WILLIAM G. ANLYAN, M.D.; DERYL HART, M.D.; NICHOLAS G. GEORGIADE, M.D.; MARY A. POSTON, M.A.
AMA Arch Surg. 1954;68(1):28-32. doi:10.1001/archsurg.1954.01260050030004.
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IT HAS been of interest during the past two years to compare the effectiveness of oxytetracycline (Terramycin) and neomycin in the preoperative preparation of the colon and rectum.

The late Dr. John Lockwood1 emphasized that in intestinal surgery chemotherapy of any type was secondary in importance to a good anastomosis on a decompressed bowel with a good blood supply. Poth2 has shown that there is a much improved quality of healing of large bowel anastomoses performed in dogs after the preoperative use of intestinal antiseptics.

Dearing and Needham3 and others * have reported on the effect of oxytetracycline on the intestinal bacterial flora of patients, with special reference to the preoperative use of oxytetracyline. Poth and his associates † have reported on the effectiveness of neomycin alone and of neomycin combined with phthalylsulfathiazole in the intestinal antisepsis of patients prior to operation. These studies were conducted on 51

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